How should I use aluminum chloride hexahydrate? Properly discard this product when it is expired or no longer needed. You may report side effects to Health Canada at 1-866-234-2345. Use your next dose at the regular time. Aluminum chloride therapy, mostly effective for axillary hyperhidrosis, was first described in 1916. This medication is used to help control excessive sweating. Keep container tightly closed. All rights reserved. Canada residents can call a provincial poison control center. This brief focuses on the utilization of aluminum chloride in dermatologic hemostasis and provides a table of alternative caustic agents used for hemostasis. Discuss the risks and benefits with your doctor. WebMD does not provide medical advice, diagnosis or treatment. [134] Concentrations of 10% to 15% and up to 30% are used in compounded formulations to treat axillary and palmoplantar hyperhidrosis, respectively. A mechanism underlying this obstruction has been proposed: the metal ions precipitate with mucopolysaccharides, damaging epithelial cells along the lumen of the duct and forming a plug that blocks sweat output. International Hyperhidrosis Society has been awarded as a Top-Rated NonProfit for eight years in a row! If needed, dry the affected area with a hair dryer on the warm setting for a few minutes. Follow all directions on your prescription label and read all medication guides or instruction sheets. © 2003-2020 International Hyperhidrosis Society. Apply a thin layer of this medication to the affected area, usually once daily at bedtime for 2 to 3 days until the sweating is controlled, then once or twice a week thereafter or as directed by your doctor. If applying on the underarms, wear a shirt. Many people using this medication do not have serious side effects. [58] If the patient regularly shaves the axillary region, it is best to wait 24 to 48 hours after shaving before applying the medication to decrease irritation. See What It Could Be. US residents can call their local poison control center at 1-800-222-1222. It is not known whether this medication passes into breast milk. [58] Several studies have shown that aluminum salts cause an obstruction of the distal sweat gland ducts. Several studies have shown that aluminum salts cause an obstruction of the distal sweat gland ducts. [58] In one series of 691 patients, pruritus was slight and short in duration in 70%, moderate in 21%, and severe in 9%, while skin irritation was moderate in 36% and severe in 14%. [148] However, another study showed that plastic film occlusion over the aluminum-salt-treated area was not necessary. Although many recommend absolute alcohol as the best vehicle for minimizing irritation, a large series of patients followed for as long as a decade has shown that an aqueous vehicle thickened with methylcellulose to create a gel was the most effective formulation. Other uses of aluminum chloride include the production of organic chemicals, paint, wood Hyperhidrosis is a medical condition in which a person sweats excessively and unpredictably. [59] Other metallic salts such as zirconium, vanadium, and indium are thought to work by the same mechanism. Before using this medication, tell your doctor or pharmacist your medical history. Hyperhidrosis is a medical condition in which a person sweats excessively and unpredictably. [44], There are individual case reports and small series of patients with facial hyperhidrosis or gustatory sweating (Frey’s syndrome) who had a clinical response to aluminum chloride treatment. The percentage of aluminum chloride varied with the site treated—10% to 25% for the axillae and 30% to 40% for the palms and soles. This is not a complete list of possible side effects. Topical medicine is for use only on the skin. Read the reviews and add your own. Do not share this medication with others. Please tell us where you sweat so we can help you and others. No images are available for this medication. Please tell us who you are in the hyperhidrosis community. [58] Some of these salts are more effective than aluminum salts, but aluminum salts have been used for over 80 years, are inexpensive and nontoxic, and remain the common active ingredient of most preparations.[58]. If applying on the hands or feet, wrap the area with plastic wrap and cover with a mitten or sock. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. [145], Following a recommended regimen may enhance efficacy and reduce the incidence of adverse effects. The affected area should be dry before the medication is applied. The purpose of this column is to focus on some of the more common drugs used in dermatology, specifically their mechanism of action and routine alternatives (if available). [148] Irritated skin can be treated with topical HC cream for up to two weeks if irritation persists. People with hyperhidrosis may sweat even when the temperature is cool or when they are at rest. Things to remember when you fill your prescription. [134] If irritation persists beyond that point, a dermatology consult should be obtained. [148] Aluminum chloride should remain on the skin for 6 to 8 hours to be effective. Feeling Stressed? The authors found that ethylenediaminetetraacetic acid (EDTA), a chelating agent, can reverse the staining blockage. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. Use this medication cautiously to avoid contact with clothes, bed linens, other fabrics, or metals. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Darst Dermatology is conveniently located at 11301 Golf Links Drive North, Charlotte, NC 28277. This product may contain inactive ingredients, which can cause allergic reactions or other problems. In the morning, wash the area with soap (or shampoo if treating the scalp) and water, and then towel dry. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Do not use near an open flame. This medicine may be harmful if swallowed. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. OTHER NAME(S): Aluminum Chloride Solution. [58], Long-term histologic studies of eccrine glands in patients on chronic aluminum salt treatment have shown destruction of secretory cells, accounting for the clinical finding of reduced severity of hyperhidrosis, as reflected by the need for less-frequent treatments. [58] In that study, various concentrations were evaluated, and the authors concluded that 15% was as effective as 20% and was better tolerated. If you notice other effects not listed above, contact your doctor or pharmacist.

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