Methylene diphenyl diisocyanate (MDI) in commercial form typically exists as a mixture of 4,4'-MDI (monomer) and certain oligomers of MDI (Encyclopedia of Chemical Technology, 1983). Action Plan [RIN 2070-ZA15] I. Overview . None of the females who died had been classified as receiving either higher or lower diisocyanate … Unusual Fire / Explosion Hazards A hazardous pressure buildup could result due to reaction with water producing CO The content of monomeric MDI generally is between 45% and 65% on a w/w basis (Mobay, 1983). Environmental Protection Agency. ISBN 0-471-95812-3 (alk. j�����rk�&~�P�{���:ߕ�Lc��v�t,|���[Հ�뤳R�{&w��U�3�ߏ������Y"��0��N���أ���~�*�����;��0� �&�x�j:h%����|�s�D�u�~@���s���y���+|�M���%)x�$�6���?R�H�l�ydC�^U�U��yy�XI����&4�+��«Ɛ��&�x)ga�`gWp4�+��I��B���IE1�f@�Ƈ{I�|�+�MnV�q�Q�a|ςk8@�gm� 4,4'-Diphenylmethane diisocyanate, MDI, Methylene di-p-phenylene ester of isocyanic acid, Methylene bis(4-phenyl isocyanate) White to light-yellow, odorless flakes. Repeated contact may cause allergic reactions in very susceptible persons. There was some suggestion of increased risk at the higher exposure level for lung cancer with a relative risk of 126 (95% CI=39-409) and respiratory diseases(95% CI=54-573). Implementing an Isocyanate Safety Plan for . MDI is the least hazardous of the commonly available isocyanates, but is not benign. Includes bibliographical references and index. Gilbert, and S.M. [Note: A liquid above 99°F.] According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may … However, it, like the other isocyanates, is an allergen and sensitizer. {�>~t0H:����B� paper) 1. Isocyanates–Safety measures. ��C%�2����8���7���,�����W� ���"+�R��֮H��Z]�Ԉq}m����^��'��o{"w4�e�K�XJ)��~E��Z�x]�XL{>��R Hazardous Substances Data Bank (HSDB) MDI usually occurs as a mixture of several isomers and oligomers: one common mixture is approximately 30-40% diphenylmethane-4,4'-diisocyanate, 2.5-4.0% diphenylmethane-2,4'-diisocyanate, 0.1-0.2 % diphenylmethane-2,2'- diisocyanate, and … "H��Vtr�~���(8y�O�G�4���2)cf��x3���Juq5.m�)��]1! (3) MDI is the usual abbreviation for monomeric methylene diphenyl diisocyanate, (CAS# 101-68-8). 0 Skin corrosion / irritation: Can cause skin irritation. Compare… If in a solution it may or may not burn depending on the nature of the material and/or the solvent. 389 0 obj <>stream Methylenediphenyl diisocyanate–Safety measures. �b5 The 3315 E. Division Street • Arlington, TX 76011 A -PMDI Safety Data Sheet This Action Plan addresses the use of methylene diphenyl diisocyanate (MDI) and related compounds (See Appendix 1) in products that may result in consumer and general population Implementing an Isocyanate Safety Plan for . Its very low vapour pressure reduces its hazards during handling compared to the other major isocyanates (TDI, HDI). In contrast to bronchial asthma, alveolitis has been reported in isolated case Hazard statements: Causes skin irritation Causes eye irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction May cause cancer via inhalation of respirable dust May cause respiratory irritation May cause damage to organs through prolonged or repeated exposure May form combustible dust concentrations in air 3. On occasion, alveolitis or hypersensitivity pneumonitis, may result from diisocyanate exposure. Methylenediphenyl diisocyanate–Safety measures. �>Zs/ջ���(eF��� /#ȵ�P��9ɯ��L��"Ï�!r^8�p�0lW�m�0��ezHA���!��щ�J�0���zA��OO�e�2�h�j���KЅ|uW�e�dY��իj�k�|��[����u�K��E�$��oNV@�L��Y������ ���u�W[�*��{�����N�#�C�|Ej7o � z�$���X��.��i�0q ���$��Az��n�(X6�]��� �{8ᯨ�4�݂�#�.�F{�f��R��ڗ�9P�f�i��O97¿R��ߝ�I�z�����(I�4��Z:��?/ֶ,�/����67���M��'�K�-܂��g�Mh�0E ��N�K��>"� ��4��^�ַ z�IS�����Jx�ΐ�m�h�. Spray Polyurethane Foam (SPF) Poor controls and work practices during polyurethane foam spraying can lead to health effects from exposure to MDI (methylene diphenyl diisocyanate) and its pre-polymers. A source book and practical guide / edited by D.C. Allport, D.S. p. cm. Methylene Diphenyl Diisocyanate (MDI) And Related Compounds . Toxicological Review of Methylene Diphenyl Diisocyanate (MDI) (CAS No. It is not soluble in water. Coughing with chest pain or tightness may also occur, frequently at night. 6.U.S. Short-term inhalation exposure to isocyanates can cause respiratory and mucous membrane irritation. Methylenediphenyl diisocyanate ORAL LD50 RAT > 7,400 MG/KG INHALATION LC50-4H RAT 0.37 MG/L DERMAL LD50 RABBIT > 6,200.00 MG/KG This product is a mixture. Roofers and insulation workers can be exposed to MDI by breathing it in, through skin ¿™¯§ÒèÙ9�a�í*�‰O8&1ÅÄZ+håçÛÈ tLfëÓ±irÈN²�;:;ì]ìŞz6Y‰O©gçÌ(dr“sèTPnëN›cõU˜OÁcÑá‚*,›N…©ÚÛm¶öÎîª. %PDF-1.6 %���� %%EOF Handling MDI requires strict engineering controls and personal protective equipment. 2. Gilbert, and S.M. Unless noted, the information below is based on components. Hazard Recognition. It is used to make plastics. Outterside. A source book and practical guide / edited by D.C. Allport, D.S. Persons developing sensitivity to isocyanates may have dangerous systemic reactions to extremely small exposures, including respiratory failure. 349 0 obj <> endobj National Center for Environmental Assessment, Office of Research and Development, Research Triangle Park, NC. 101-68-8 and 9016-87-9) in Support of Summary Information on the Integrated Risk Information System (IRIS). �v�3�KW���u��L���*m�7eP����c�נ +�7�*�v1�� C���Y��O��471��W�u�� Spray Polyurethane Foam (SPF) Poor controls and work practices during polyurethane foam spraying can lead to health effects from exposure to MDI (methylene diphenyl diisocyanate) and its pre-polymers. Symptoms include eye and nose irritation, dry or sore throat, runny nose, shortness of breath, wheezing and laryngitis. endstream endobj 350 0 obj <>>>/Filter/Standard/Length 128/O(�9A����J\\�&�����=���5P�n�Ͽ2_)/P -1340/R 4/StmF/StdCF/StrF/StdCF/U(R.sNt�JG�cᗗv�� )/V 4>> endobj 351 0 obj <> endobj 352 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 353 0 obj <>stream Includes bibliographical references and index. EFFECT OF OVEREXPOSURE -CHRONIC HAZARDS:Repeated or prolonged exposure may cause respiratory system damage. Decontaminate equipment and protective clothing prior to reuse. p. cm. Prolonged or repeated inhalation of dust may cause lung Isocyanates–Safety measures. The following references aid in recognizing and evaluating hazards associated with isocyanates in the workplace. 2. Outterside. The “polymeric” forms of MDI, which typically consist of 30-70 percent monomeric diphenylmethane diisocyanate and the balance in higher molecular weight fractions (CAS # 5873-54-1) may at times be generically referred to as MDI.

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